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KMID : 0356919940270121765
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Korean Journal of Anesthesiology
1994 Volume.27 No. 12 p.1765 ~ p.1770
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The Effect of Isoflurane Anesthesia on the Succinylcholine-Induced Muscle Fasciculations in Children
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양현정
김건식/김동욱/신옥영/신광일
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Abstract
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Forty children were anesthetized with either thiopental 5mg/kg followed by succinylcholine 1.5mg/kg I.V. or with isoflurane 3.5 vol% in 66% nitrous oxide in oxygen via a face mask followed by succinylcholine 1.5mg/kg I.V..
The study was randomized, in the thiopental group, fasciculation were seen in all children and in the isoflurane group, in 10 of 20 children (p<0.001).
The intensity of the fasciculation was 1.6±0.7 in the thiopental group an 0.6±0.4 in the isoflurane group (p<0.001).
The duration of fasciculation was 35.6±13.6sec in the thiopental group and 9.0±8.0 sec in the isoflurane group (p<0.001).
No cardiac arihythmias were noted in either group, but heart rates were increased significantly after intubation in both group (p<0.001).
In conclusion, isoflurane in nitrous oxide may inhibit succinylcholine-induced muscle fasciculation in children.
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